For years, literary authors and scientific researchers have described the association between illness and losses through death, separation, divorce, or other termination of relationships. “Anniversary reactions” to dates of such events have often yielded pathophysiological responses. The field of psychoimmunology has attempted to identify the process and anatomical routes through which such events are mediated. Apparently such emotional stresses involve hypothalamic pathways leading to the complexities of the immune system. Key elements of this system include T- and B-lymphocytes, natural killer cells, macrophages, complement, and polymorphonuclear leukocytes. Current studies include all of the above components.